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Topic: The meaning of life (Read 4711 times)
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Scalare
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The nausea really comes from the way it acts on your digestive system (the same way serotonin does this), and is only present with most people 15 minutes to 45 minutes after consuming. After puking or enduring the nausea it gets a lot better.
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Zanthius
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The people I know who have had such a mystical experience (most of them on LSD and MXE and MDMA, never on mushrooms) are generally more open minded and less stubborn in such discussions.
Another thing, I am not necessarily saying that mushrooms are better to give "mystical experiences" than those drugs. I actually like Ibogaine more than mushrooms. Maybe also Mescaline. Never tried MXE and LSD. And of course they could also give you "mystical experiences" . I also think different people feel differently about different drugs. So maybe for you MXE is indeed best to give you mystical experiences, but not necessarily for me. The important thing it just that we get mystical experiences somehow I guess. Doesn't need to be from mushrooms, even if I know that they will give people mystical experiences.
The main reason why I advocate for mushrooms, is because they have a low toxicity, and because I have lots of experiences with them. But I am not claiming that they necessarily are the best drug to give you mystical experiences. That could very well be MXE.
Here. I made this just for you:
However, I do not guarantee for the safety of all these drugs. Several people have for example died from Ibogaine. I think mushrooms and LSD have the lowest toxicities, while Ibogaine has one of the highest.
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« Last Edit: July 11, 2017, 10:57:57 pm by Zanthius »
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Scalare
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I think nobody ever died from LSD. Some people (20) died from MXE of which 8 have died from it alone. As said it doesn't combine well with alcohol.
It was actually created quite recently by a guy with an amputated limb who experienced heavy phantom pains, and developed the chemical which really helps against it.
I guess since it's a dissociative, with the most notable effect when you consume it for the first time, being that you experience your hands not being yours anymore, it could also make you dissociate from that amputated limb.
He regrets right now making that after the first death occured. But right now people are researching using small amounts of it to cure depression, for which it works remarkably. It changes something in the working of your brain that makes you let go of things and worry less more easily.
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Zanthius
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Absolutely! But that you can use it to let go of things also makes it more addictive. You run the risk of taking it after a bad day, to more easily solve that thing in your head.
Yes, this is kinda why I have been a little skeptical about MXE. All NMDA receptor antagonist are anesthetics, and probably therefore a little bit addictive. I also don't quite understand how it can make your memory better. The NMDA receptor is definitely involved in memory, but I thought NMDA receptor agonists (the opposite type of drugs) were used to get better memory, not NMDA receptor antagonist like ketamine and methoxetamine. To help you "let go", also doesn't sound like something that would make your memory better.
Anyhow. Classification of these drugs as either agonists or antagonist might be somewhat misleading. There are often subtypes of receptors and drugs often interact with multiple receptors. So it could very well be that methoxetamine makes your memory better. It is just the opposite of what our current theoretical understanding of NMDA receptor would say. But there is A LOT we don't know about how the brain works. So, since I have never tried methoxetamine, I am going to believe you since you have actually tried it.
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« Last Edit: July 12, 2017, 12:37:28 am by Zanthius »
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Zanthius
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Actually, I have a theory of why you might be getting better memory now:
And about letting go. Here is a song about it: https://www.youtube.com/watch?v=OeARhinr7rY (maybe something people could listen to, while they are in the period for letting go).
When you use methoxetamine to block NMDA receptors, the body might start producing more glutamate. After most of the methoxetamine has been cleansed from your body, you might still have a surplus of glutamate, which gives you better memory. Be aware though that having an excess of glutamate in your system can be neurotoxic (https://en.wikipedia.org/wiki/Excitotoxicity). So getting better memory might come at a price. It might actually kill your neurons.
Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins). Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the mammalian CNS.[9] During normal conditions, glutamate concentration can be increased up to 1mM in the synaptic cleft, which is rapidly decreased in the lapse of milliseconds.[10] When the glutamate concentration around the synaptic cleft cannot be decreased or reaches higher levels, the neuron kills itself by a process called apoptosis.[11][12]
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« Last Edit: July 12, 2017, 03:07:45 pm by Zanthius »
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Scalare
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I think the addiction will be more psychological instead of fysiological  .
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Zanthius
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Here is a modified version of Maslow's hierarchy of needs:
http://www.archania.org/magic_mushrooms_and_the_passion_for_mystery.html
This also makes me think of games full of mysteries (Star Control 2 for example), compared to MMORPG's where the focus mostly is upon character development (self-actualization). That should also make it pretty clear why I am writing in this forum, and not in a forum for an MMORPG. Most of you probably feel a great passion for mysteries, since you were so interested in Star Control 2.
EDIT: I just realized that there are numerous of problems with Maslow's hierarchy of needs. I have now created a completely new version, where I have also changed on the lower levels. The need for community should be very low... just above the need for survival. Humans are group animals. We cannot function properly without community. We wouldn't even have language without community. Also. The "need for community" tends to take precedence over the "need for procreation" among group animals, since it isn't necessarily imperative for all members of a community to participate in procreation. However, there is often tension between the "need for procreation" and the "need for community". Sigmund Freud wrote extensively about this.
I decided to call it "passion for mystery", rather than "need for mystery". Here is a song I like about passion: https://www.youtube.com/watch?v=NYiNNlfYAMw
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« Last Edit: July 24, 2017, 11:17:38 pm by Zanthius »
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